Welcome!

CRM Authors: Xenia von Wedel, Ian Khan, PR.com Newswire, Steve Mordue

News Feed Item

Waters New ACQUITY UPLC H-Class Method Development System Takes Automation to Higher Level

Combined with Fusion Method Development Software, the New System Produces Robust Methods Faster using Quality-by-Design Guidelines with Increased Chromatographic Flexibility

MILFORD, Mass., June 21 /PRNewswire-FirstCall/ -- Waters Corporation (NYSE: WAT) today unveiled its new Waters® ACQUITY UPLC® H-Class Method Development System that automates liquid chromatography method development according to Quality-by-Design (QbD) guidelines to produce robust, fit-for-purpose methods in dramatically less time than traditional processes. The superior performance of the new system stems from the power and integration of four class-leading components: ACQUITY UPLC H-Class; Fusion Method Development(TM) Software; Empower(TM) 2 Chromatography Data Software, and; Waters Method Development Chemistry Kits.

"The ACQUITY UPLC H-Class Method Development System combines industry-leading separation capabilities with cutting-edge, automated software and data management to consistently produce rugged, robust LC methods in a fraction of the time," said Warren Potts, Pharmaceutical Business Director for the Waters Division. "The chromatographic flexibility and power of Waters' recently introduced ACQUITY UPLC H-Class system is transforming modern method development as laboratories continue to adopt new UPLC methods and transfer older HPLC methods to UPLC. Now the integration of Fusion Software (S-Matrix Corporation) with ACQUITY UPLC H-Class has taken automated method development to entirely new levels of efficiency and productivity, thereby reducing costs and decreasing time-to-market."

The key to the ACQUITY UPLC H-Class Method Development System is its use of QbD-based methodology for LC method development, allowing scientists to develop the best possible method much faster and with greater confidence. Fusion works with Empower 2 and ACQUITY UPLC to increase lab efficiency by designing statistically-valid experiments and automatically reconstructing them in Empower 2 as fully ready-to-run sequences. Fusion uses the resulting data to generate parameter-effects models which establish the final design and operating spaces for truly optimized LC methods. With new features introduced on the ACQUITY UPLC H-Class such as multi-solvent blending, versatile column management options, and reliable Method Development Kits available in a variety of chemistries, the ACQUITY UPLC H-Class Method Development System's capabilities to ensure a quality method is developed the first time is unmatched.

To benchmark the effectiveness of Fusion Method Development Software used in combination with Empower 2 and ACQUITY UPLC, a large pharmaceutical company demonstrated that it was possible to reduce method development time for a complex drug product from 45-60 days to two days when compared to the conventional one-factor-at-a-time development approach.(1)

The ACQUITY UPLC H-Class Method Development System also addresses regulatory recommendations to incorporate robustness into LC method development (ICH Q2B Validation of Analytical Procedures - Methodology). Utilizing a patented approach built on sound statistical process control techniques, the Fusion Software computes and models the impact of key chromatographic parameters on method robustness. This enables identification of methods optimized for both mean performance and robustness without the need for any additional experiments. Establishing the final design space for a method in this manner creates the basis for flexibility and continuous improvement (ICH Q8(R2) Pharmaceutical Development).

Pharmaceutical organizations can standardize their approach to LC with this common technology platform that makes the future transition from HPLC to efficient UPLC-based methods straightforward and practical - from discovery through to product release testing. With additional tools such as Method Transfer and Method Validation Kits, seamless transfer from an HPLC to a UPLC, or vice versa, is ensured.

More information on the ACQUITY UPLC H-Class Method Development System is available on Waters web site: www.waters.com/method.

About ACQUITY UPLC (www.waters.com/uplc)

The ACQUITY UPLC family of systems eliminates significant time and cost per sample from analytical processes while improving the quality of results. By outperforming traditional or optimized HPLC, the system allows chromatographers to work at higher efficiencies with a much wider range of linear velocities, flow rates, and backpressures. UPLC Technology, which has been adopted successfully in laboratories around the world for the most demanding separations, is a highly robust, dependable, and reproducible system. What differentiates the system's holistic design is Waters' patented sub-2 micron hybrid particle chemistry, significant benefits over today's HPLC systems equipped with standard 5 micron particle chemistries.

About S-Matrix (www.smatrix.com)

S-Matrix Corporation develops advanced Design-of-Experiments (DOE) based software that automates R&D experimental work according to accepted Quality-by-Design principles and methodologies. Strategic business alliances with key industry and academic customers, analytical instrument, and process equipment companies enable S-Matrix to rapidly bring to market innovative Automated Experimentation techniques and software for targeted industry applications.

About Waters Corporation (www.waters.com)

For more than 50 years, Waters Corporation (NYSE: WAT) has created business advantages for laboratory-dependent organizations by delivering practical and sustainable innovation to enable significant advancements in such areas as healthcare delivery, environmental management, food safety, and water quality worldwide.

Pioneering a connected portfolio of separations science, laboratory information management, mass spectrometry and thermal analysis, Waters technology breakthroughs and laboratory solutions provide an enduring platform for customer success.

With revenue of $1.5 billion in 2009 and 5,200 employees, Waters is driving scientific discovery and operational excellence for customers worldwide.

1. A Quality-by-Design Methodology for Rapid LC Method Development, Part III. Ira Krull, Michael Swartz, Joseph Turpin, Patrick H. Lukulay, Richard Verseput. LCGC North America, April 1 2009

Waters, ACQUITY UPLC, UPLC, and Empower are trademarks of Waters Corporation. Fusion Method Development is a trademark of S-Matrix Corporation.

SOURCE Waters Corporation

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

IoT & Smart Cities Stories
Two weeks ago (November 3-5), I attended the Cloud Expo Silicon Valley as a speaker, where I presented on the security and privacy due diligence requirements for cloud solutions. Cloud security is a topical issue for every CIO, CISO, and technology buyer. Decision-makers are always looking for insights on how to mitigate the security risks of implementing and using cloud solutions. Based on the presentation topics covered at the conference, as well as the general discussions heard between sessio...
The platform combines the strengths of Singtel's extensive, intelligent network capabilities with Microsoft's cloud expertise to create a unique solution that sets new standards for IoT applications," said Mr Diomedes Kastanis, Head of IoT at Singtel. "Our solution provides speed, transparency and flexibility, paving the way for a more pervasive use of IoT to accelerate enterprises' digitalisation efforts. AI-powered intelligent connectivity over Microsoft Azure will be the fastest connected pat...
CloudEXPO has been the M&A capital for Cloud companies for more than a decade with memorable acquisition news stories which came out of CloudEXPO expo floor. DevOpsSUMMIT New York faculty member Greg Bledsoe shared his views on IBM's Red Hat acquisition live from NASDAQ floor. Acquisition news was announced during CloudEXPO New York which took place November 12-13, 2019 in New York City.
BMC has unmatched experience in IT management, supporting 92 of the Forbes Global 100, and earning recognition as an ITSM Gartner Magic Quadrant Leader for five years running. Our solutions offer speed, agility, and efficiency to tackle business challenges in the areas of service management, automation, operations, and the mainframe.
Apptio fuels digital business transformation. Technology leaders use Apptio's machine learning to analyze and plan their technology spend so they can invest in products that increase the speed of business and deliver innovation. With Apptio, they translate raw costs, utilization, and billing data into business-centric views that help their organization optimize spending, plan strategically, and drive digital strategy that funds growth of the business. Technology leaders can gather instant recomm...
In an age of borderless networks, security for the cloud and security for the corporate network can no longer be separated. Security teams are now presented with the challenge of monitoring and controlling access to these cloud environments, at the same time that developers quickly spin up new cloud instances and executives push forwards new initiatives. The vulnerabilities created by migration to the cloud, such as misconfigurations and compromised credentials, require that security teams t...
AI and machine learning disruption for Enterprises started happening in the areas such as IT operations management (ITOPs) and Cloud management and SaaS apps. In 2019 CIOs will see disruptive solutions for Cloud & Devops, AI/ML driven IT Ops and Cloud Ops. Customers want AI-driven multi-cloud operations for monitoring, detection, prevention of disruptions. Disruptions cause revenue loss, unhappy users, impacts brand reputation etc.
As you know, enterprise IT conversation over the past year have often centered upon the open-source Kubernetes container orchestration system. In fact, Kubernetes has emerged as the key technology -- and even primary platform -- of cloud migrations for a wide variety of organizations. Kubernetes is critical to forward-looking enterprises that continue to push their IT infrastructures toward maximum functionality, scalability, and flexibility. As they do so, IT professionals are also embr...
@CloudEXPO and @ExpoDX, two of the most influential technology events in the world, have hosted hundreds of sponsors and exhibitors since our launch 10 years ago. @CloudEXPO and @ExpoDX New York and Silicon Valley provide a full year of face-to-face marketing opportunities for your company. Each sponsorship and exhibit package comes with pre and post-show marketing programs. By sponsoring and exhibiting in New York and Silicon Valley, you reach a full complement of decision makers and buyers in ...
While the focus and objectives of IoT initiatives are many and diverse, they all share a few common attributes, and one of those is the network. Commonly, that network includes the Internet, over which there isn't any real control for performance and availability. Or is there? The current state of the art for Big Data analytics, as applied to network telemetry, offers new opportunities for improving and assuring operational integrity. In his session at @ThingsExpo, Jim Frey, Vice President of S...